Electrophysiology
Anticoagulation in AF
DOACs vs warfarin, bleeding risk, and stroke prevention
Emerging pathwayAlso known as: DOAC AF, NOAC atrial fibrillation, AF anticoagulation
3,978
Clinical questions
209
Evidence-backed
100
Claims analyzed
Electrophysiology
DOACs vs warfarin, bleeding risk, and stroke prevention
Synthesized from 209 evidence-backed clinical questions linked to this topic — 83 supporting the intervention, 75 against the intervention, 10 still contested.
No clear lean — the placed evidence is contested
83
Favor benefit
40% of all
75
Favor harm
36% of all
41 more (20%) still untested — not placed on the axis.
Low certainty on 76% of questions
Does ethanol vs placebo improve outcomes in Persistent atrial fibrillation?
Low Certainty− Favors harmethanol vs placebo
59 studies (25,167,216 patients) provide low-certainty evidence against benefit of ethanol for the outcome in Persistent atrial fibrillation.
Does beta blockers vs placebo improve outcomes in Atrial Fibrillation?
Low Certainty+ Favors benefitbeta blockers vs placebo
19 studies (4,622,940 patients) provide low-certainty evidence for benefit of beta blockers for the outcome in Atrial Fibrillation.
Does oral anticoagulants vs placebo improve Stroke (Safety Event) in Atrial Fibrillation?
Insufficient~ Mixed resultsoral anticoagulants vs placebo · Stroke (Safety Event)
11 studies (240,230 patients) provide insufficient evidence with mixed findings regarding oral anticoagulants for Stroke (Safety Event) in Atrial Fibrillation.
Does noac vs salicylic acid 120 mg/ml topical solution improve outcomes in Atrial Fibrillation?
Insufficient~ Mixed resultsnoac vs salicylic acid 120 mg/ml topical solution
8 studies (746,143 patients) provide insufficient evidence with mixed findings regarding noac for the outcome in Atrial Fibrillation.
Emerging evidence with 100 primary claims
Specific, answerable questions in this area — each with its own synthesized evidence and consensus. Open one to see the forest plot, source trials, and how the consensus has changed over time.
Does oral anticoagulation vs placebo improve All-Cause Mortality in Atrial Fibrillation?
Low Certainty+ Favors benefitoral anticoagulation vs placebo · All-Cause Mortality
Does dabigatran vs warfarin improve outcomes in HEART-VALVE, MECHANICAL?
Low Certainty+ Favors benefitdabigatran vs warfarin · Ventricular Arrhythmia
Questions where the synthesized consensus has shifted as new trials were indexed.
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Haemorrhagic complications following cataract and vitreoretinal surgery with sub-Tenon’s block in patients receiving non–vitamin K oral anticoagulant agents: A prospective audit
Anaesthesia and Intensive Care — Jan 2022
Perioperative Anticoagulation Management
Critical Care Nursing Quarterly — Feb 2022
Periprocedural Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant Undergoing a Digestive Endoscopy
The American Journal of Gastroenterology — Hansen-Barkun C — Nov 2022
Updated recommendations for warfarin reversal in the setting of four‐factor prothrombin complex concentrate
The Medical Journal of Australia — Robinson D — Nov 2024
Perioperative Factor Xa Inhibitor Discontinuation for Patients Undergoing Procedures With Minimal or Low Bleeding Risk
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Anticoagulation in AF (also known as DOAC AF, NOAC atrial fibrillation, AF anticoagulation). DOACs vs warfarin, bleeding risk, and stroke prevention
Synapse tracks 8 specific clinical questions in Anticoagulation in AF, each synthesized independently from its own trial evidence. They include: "Does oral anticoagulation vs placebo improve All-Cause Mortality in Atrial Fibrillation?"; "Does dabigatran vs warfarin improve outcomes in HEART-VALVE, MECHANICAL?"; "Does rivaroxaban vs apixaban improve outcomes?"; "Does oral anticoagulants vs placebo improve Intracranial Hemorrhage in Atrial Fibrillation?"; "Does warfarin vs placebo improve All-Cause Mortality in Atrial Fibrillation?".
As of 2026-08-24, the scientific consensus on Anticoagulation in AF is emerging. Emerging evidence with 100 primary claims Based on 100 analyzed claims across Synapse's enriched corpus, the evidence shows.
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/anticoagulation-in-af.
Deterministic synthesis from Synapse's enriched corpus — 129 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Anticoagulation in AF paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
Search Anticoagulation in AF papersPowered by Synapse — AI-enriched analysis of 600,000+ peer-reviewed papers
JAMA Network Open — Lee S — Feb 2025
Across this topic’s most recent indexed papers.
Scripps Research Institute
h-index 204 · 186k citations
Population Health Research Institute
h-index 125 · 69k citations
McMaster University Medical Centre
h-index 119 · 76k citations
Cleveland Clinic
h-index 119 · 57k citations
Amsterdam University Medical Centers
h-index 113 · 58k citations
McMaster University
h-index 112 · 55k citations
Most-cited researchers publishing on Anticoagulation in AF.
