FIGURE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Manjunath Siddappa; Shahid Hussain; Sajad A. Wani; Jason White; Hancong Tang; Jaimie S. Gray; Hedieh Jafari; Hsu-Chang Wu; Mark D. Long; Isra Elhussin; Balasubramanyam Karanam; Honghe Wang; Rebecca Morgan; Gary Hardiman; Isaacson B. Adelani; Solomon O. Rotimi; Adam B. Murphy; Larisa Nonn; Melissa B. Davis; Rick A. Kittles; Chanita Hughes Halbert; Lara E. Sucheston‐Campbell; Clayton Yates; Moray J. Campbell

doi:10.1158/2767-9764.29619058

Key Points

African American prostate cancer displays unique vitamin D receptor cistrome and transcriptome relationships.
Differential enrichment of regions was identified using ATAC-seq, highlighting specific epigenetic patterns.
Motif enrichment analysis indicated significant enrichment of transcription factor families linked to vitamin D receptor activity.
Findings may advance understanding of prostate cancer disparities in African American populations.

Implication

ATAC-seq reveals varied vitamin D receptor cistrome-transcriptome relationships in prostate cancer, suggesting epigenetic regulation differences in African Americans.

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Cite This Study

Siddappa et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd91f https://doi.org/10.1158/2767-9764.29619058

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FIGURE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Key Points

Implication

Abstract

Discussion

Cite This Study

FIGURE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Key Points

Implication

Abstract

Discussion

Cite This Study

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