FIGURE 4 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Key Points

Distinct relationships between vitamin D receptor and transcriptome were observed in African American prostate cancer.
RNA-seq identified significant differentially expressed genes (DEGs) with logPV > 1 and absFC > 0.37.
Cell lines HPr1AR, LNCaP, RC43N, and RC43T were used to explore the effects of vitamin D on gene expression.
Findings highlight the potential role of BAZ1A in regulating vitamin D receptor signaling effects in cancer.

RNA-seq analysis reveals differences in vitamin D receptor signaling in African American prostate cancer cells, suggesting BAZ1A's regulatory role.

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Siddappa et al. (2025) studied this question.

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