TABLE 1 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Key Points

MAIN FINDING: Prostate cancer shows unique vitamin d receptor cistrome-transcriptome relationships influenced by baz1a.
KEY EVIDENCE: Gene expression linked to vitamin d receptor activity revealed significant overlap with baz1a-regulated genes.
APPROACH: The analysis focused on 1α,25(OH)2D3-regulated genes and their relationship with VDR-binding sites.
SIGNIFICANCE: Understanding these relationships may lead to better therapeutic strategies for prostate cancer in African American populations.

The study demonstrates distinct relationships of vitamin d receptor activity and gene expression in prostate cancer, suggesting a role for baz1a.

Overlap of BAZ1A-dependent 1α,25(OH)₂D₃-regulated gene expression with genes annotated to 1α,25(OH)₂D₃-regulated NF regions and VDR-binding sites

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Siddappa et al. (2025) studied this question.

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