TABLE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Manjunath Siddappa; Shahid Hussain; Sajad A. Wani; Jason White; Hancong Tang; Jaimie S. Gray; Hedieh Jafari; Hsu-Chang Wu; Mark D. Long; Isra Elhussin; Balasubramanyam Karanam; Honghe Wang; Rebecca Morgan; Gary Hardiman; Isaacson B. Adelani; Solomon O. Rotimi; Adam B. Murphy; Larisa Nonn; Melissa B. Davis; Rick A. Kittles; Chanita Hughes Halbert; Lara E. Sucheston‐Campbell; Clayton Yates; Moray J. Campbell

doi:10.1158/2767-9764.29619004

Key Points

The study identifies unique relationships between vitamin D receptor activity and gene expression in prostate cancer.
Data shows significant overlaps in genes regulated by serum 25(OH)D3 and those related to obesity.
Participants included African American men diagnosed with prostate tumors, highlighting specific health issues within this demographic.
Findings suggest obesity could impact the effectiveness of vitamin D in regulating prostate cancer-related genes.

Implication

This analysis reveals distinct vitamin D receptor interactions in prostate cancer tumors, indicating obesity may influence gene expression in African American patients.

Abstract

Percentage overlap of either serum 25(OH)D₃ vitamin D₃-regulated or obesity-regulated gene expression in prostate tumors from AA patients with genes annotated by 1α,25(OH)₂D₃-regulated NF regions and/or VDR ChIP-seq

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Siddappa et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd941 https://doi.org/10.1158/2767-9764.29619004

View at Publisher

Ask AI

Bookmark

Share

TABLE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Key Points

Implication

Abstract

Discussion

Cite This Study

TABLE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

Keep reading

More related papers