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July 23, 2025

Spatially resolved fetal and maternal cell contributions to severe Preeclampsia

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Authors

YSYara E. Sánchez-CorralesGreat Ormond Street HospitalTXTheodoros XenakisMetrica (United States)JMJose J Moreno-VillenaGreat Ormond Street Hospital

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Overview

Research shows distinct fetal-maternal cell contributions to systemic inflammation in preeclampsia, suggesting new therapy targets for early intervention.

Key Points

  • Fetal and maternal contributions to severe preeclampsia are subjected to spatial analysis in this research.
  • Key findings include immune signatures and dysfunctions in macrophages and mitochondria contributing to disease severity.
  • The approach encompasses tissue investigation beyond the placenta, examining both early and late stages of preeclampsia.
  • The implications point towards potential therapeutic strategies targeting specific immune responses to improve outcomes.

Cite This Study

Sánchez-Corrales et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdb18https://doi.org/10.1101/2025.07.18.665528
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation2026
  2. 2Genomic Insights at the Maternal-Fetal Interface: Preeclampsia Subtypes and Clinical Implications2025
  3. 3Understanding Preeclampsia: Integrating Placental Dysfunction, Immune Dysregulation and microRNA-Mediated Epigenetic Regulation2026 · 1 citations
  4. 4PLACENTAL ALTERATIONS IN SEVERE PREECLAMPSIA AND THEIR MATERNAL AND NEONATAL IMPACTS: INTEGRATIVE LITERATURE REVIEW2025
  5. 5PLACENTAL ALTERATIONS IN SEVERE PREECLAMPSIA AND THEIR MATERNAL AND NEONATAL IMPACTS: INTEGRATIVE LITERATURE REVIEW2025