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September 20, 2025

Placental Alterations in Severe Preeclampsia and Their Maternal and Neonatal Impacts: Integrative Literature Review

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Authors

LALívia de Oliveira AlvesLALuís AlvesRMRodolfo de Oliveira Medeiros

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Overview

Integrative literature review reveals placental alterations worsen maternal and neonatal outcomes, highlighting the need for better biomarkers.

Key Points

  • Placental alterations, including villous infarction and fibrinoid deposition, severely impact maternal and neonatal health.
  • Findings indicate that severe preeclampsia is linked to major clinical issues such as HELLP syndrome and intrauterine growth restriction.
  • Systematic review following evidence-based practice highlighted the importance of standardized placental evaluation protocols.
  • Adoption of biomarker panels could improve early detection and management in severe preeclampsia, potentially reducing morbidity.

Cite This Study

Alves et al. (2025) studied this question.

synapsesocial.com/papers/68d46abb31b076d99fa68033https://doi.org/10.36557/2009-3578.2025v11n2p3209-3223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PLACENTAL ALTERATIONS IN SEVERE PREECLAMPSIA AND THEIR MATERNAL AND NEONATAL IMPACTS: INTEGRATIVE LITERATURE REVIEW2025
  2. 2Spectrum of Morphological Changes in the Placenta of Women with Preeclampsia/Eclampsia and Correlation with Neonatal Morbidity2024
  3. 3Placental Dysfunction as a Common Pathway Linking Preeclampsia, Fetal Growth Restriction, and Preterm Birth: Current Evidence and Future Directions2026
  4. 4Spatially resolved fetal and maternal cell contributions to severe Preeclampsia2025 · 1 citations
  5. 5Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation2026