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September 27, 2025Open Access

Placental Alterations in Severe Preeclampsia and Their Maternal and Neonatal Impacts: Integrative Literature Review

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Authors

LALívia de Oliveira AlvesLALuís AlvesRMRodolfo de Oliveira Medeiros

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Overview

Literature review highlights placental alterations affecting maternal and neonatal outcomes in severe preeclampsia.

Key Points

  • Placental alterations in severe preeclampsia include villous infarction and oxidative stress, impacting maternal health.
  • A pattern of clinical complications such as HELLP syndrome and placental abruption emerges due to placental dysfunction.
  • Neonates face risks like intrauterine growth restriction and prematurity due to maternal placental impairment.
  • Combined biomarker panels may enhance early detection and management of severe preeclampsia, improving outcomes.

Cite This Study

Alves et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3e9eebfec0fc5236f16https://doi.org/10.36557/2009-3578.2025v11n2p3495-3509
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PLACENTAL ALTERATIONS IN SEVERE PREECLAMPSIA AND THEIR MATERNAL AND NEONATAL IMPACTS: INTEGRATIVE LITERATURE REVIEW2025
  2. 2Spectrum of Morphological Changes in the Placenta of Women with Preeclampsia/Eclampsia and Correlation with Neonatal Morbidity2024
  3. 3Placental Dysfunction as a Common Pathway Linking Preeclampsia, Fetal Growth Restriction, and Preterm Birth: Current Evidence and Future Directions2026
  4. 4Spatially resolved fetal and maternal cell contributions to severe Preeclampsia2025 · 1 citations
  5. 5Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation2026