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July 26, 2026Science AdvancesOpen Access

Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation

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Authors

YSYara E. Sánchez-CorralesGreat Ormond Street HospitalTXTheodoros XenakisMetrica (United States)JMJose J Moreno-VillenaGreat Ormond Street Hospital

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Overview

Randomized trial examines fetal and maternal cell roles in severe preeclampsia, suggesting new therapeutic targets.

Key Points

  • This research aims to elucidate the contributions of fetal and maternal cells to the pathophysiology of severe preeclampsia.
  • Interrogated fetal and maternal tissues across different stages of gestation.
  • Analyzed single-cell and spatial molecular signatures relevant to preeclampsia.
  • Assessed maternal immune signatures and their impact on systemic inflammation.
  • Identified hypoxia, angiogenic imbalance, and aberrant metabolism in placental tissues.
  • Documented maternal mitochondrial dysfunction and interferon signaling in the myometrium and membranes.
  • Highlighted impaired interactions between fetal cells and endothelial cells as contributors to maternal endothelial dysfunction.

Cite This Study

Sánchez-Corrales et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78de6https://doi.org/10.1126/sciadv.aed8964
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatially resolved fetal and maternal cell contributions to severe Preeclampsia2025 · 1 citations
  2. 2Genomic Insights at the Maternal-Fetal Interface: Preeclampsia Subtypes and Clinical Implications2025
  3. 3Understanding Preeclampsia: Integrating Placental Dysfunction, Immune Dysregulation and microRNA-Mediated Epigenetic Regulation2026 · 1 citations
  4. 4Regulation of Decidual CD8+ T cells in Preeclampsia2026
  5. 5PLACENTAL ALTERATIONS IN SEVERE PREECLAMPSIA AND THEIR MATERNAL AND NEONATAL IMPACTS: INTEGRATIVE LITERATURE REVIEW2025