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July 30, 2025Open Access

Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration

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Authors

EGElisabetta GamenEPEleonor L PriceDPDaniela Pezzolla

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Overview

Experimental approach extended heart regeneration in neonates, suggesting HIF signalling may aid in treating ischaemic heart disease.

Key Points

  • HIF signalling plays a crucial role in epicardial activation during neonatal heart regeneration.
  • Inhibition of HIF degradation improved WT1 activity and coronary vasculature in experimental models.
  • Stabilisation of HIF during neonatal heart injury led to better infarct resolution and improved heart function.
  • These findings indicate potential therapeutic strategies for enhancing myocardial survival in heart disease.

Cite This Study

Gamen et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cf0d9https://doi.org/10.7554/elife.107419.1
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  5. 5Transient Regenerative Potential of the Neonatal Mouse Heart2011 · 2,646 citations