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July 31, 2025Infectious Diseases of PovertyOpen Access

Test accuracy of loop-mediated isothermal amplification for schistosomiasis in low endemicity areas: a systematic review and meta-analysis

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Authors

XZXinjie ZhouJLJiajia LiJQJiamin Qiu

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Overview

Systematic review assesses loop-mediated isothermal amplification for schistosomiasis, indicating high diagnostic performance in various sample types.

Key Points

  • LAMP demonstrates a sensitivity of 90% and specificity of 82% for diagnosing schistosomiasis.
  • Pooled analyses from 24 studies show diagnostic odds ratio of 39, indicating excellent test performance.
  • Subgroup analyses reveal optimal sensitivity for S. japonicum and snail samples, highlighting effective diagnostics.
  • This rapid test supports the goal of schistosomiasis elimination by 2030, particularly in under-resourced regions.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf5bbhttps://doi.org/10.1186/s40249-025-01346-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of the Loop-Mediated Isothermal Amplification (LAMP) and the Kato-Katz Techniques in the Diagnosis of <i>Schistosoma mansoni</i> in Burkina Faso2024
  2. 2Rapid and Sensitive Detection of Schistosoma mansoni in the Intermediate Snail Hosts Using Loop-Mediated Isothermal Amplification (LAMP) Diagnostics2026
  3. 3Comparative DNA extraction methods to use for LAMP assay as molecular diagnosis of human schistosomes from urine samples2025 · 4 citations
  4. 4Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis2022 · 16 citations
  5. 5Multiplex LAMP-LFA for rapid field-compatible detection of environmental DNA from Schistosoma japonicum and Oncomelania hupensis quadrasi2026