Supplementary Figure 1 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Ari J. Rosenberg; Evgeny Izumchenko; Aditya Juloori; Rohan Katipally; John Cursio; Noura J. Choudhury; Zhen Gooi; Elizabeth A. Blair; Jeffrey Chin; Rifat Hasina; Augustin Vannier; Anna Starus; Frederick S. Jones; Emily L. Gramiccioni; Yuxuan Miao; Daniel J. Haraf; Everett E. Vokes; Alexander T. Pearson; Nishant Agrawal

doi:10.1158/1078-0432.29761060

Key Points

Progression free survival differs significantly between patients with rapid ctHPV-DNA clearance and those without.
Patients achieving at least 95% reduction in ctHPV-DNA after cycles 1 and 2 exhibited improved survival outcomes.
Kaplan-meier estimates reveal that ctHPV-DNA dynamics can indicate response to neoadjuvant chemotherapy in oropharyngeal cancer.
This analysis supports the potential for personalized treatment strategies based on early ctHPV-DNA clearance.

Implication

Supplementary figure shows progression free survival in patients with rapid ctHPV-DNA clearance after neoadjuvant chemotherapy, indicating treatment effectiveness.

Abstract

Supplementary Figure 1. Progression free survival Kaplan-meier estimates for patients that rapidly clear ctHPV-DNA (≥95% ctHPV-DNA reduction) after cycles 1 and 2 (red) versus patients that do not achieve rapid ctHPV-DNA clearance after cycles 1 and 2 (blue).

Discussion

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Cite This Study

Rosenberg et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcad https://doi.org/10.1158/1078-0432.29761060

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Supplementary Figure 1 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 1 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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