Supplemental Table 2 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Ari J. Rosenberg; Evgeny Izumchenko; Aditya Juloori; Rohan Katipally; John Cursio; Noura J. Choudhury; Zhen Gooi; Elizabeth A. Blair; Jeffrey Chin; Rifat Hasina; Augustin Vannier; Anna Starus; Frederick S. Jones; Emily L. Gramiccioni; Yuxuan Miao; Daniel J. Haraf; Everett E. Vokes; Alexander T. Pearson; Nishant Agrawal

doi:10.1158/1078-0432.29761072

Key Points

MAIN FINDING: Correlations were identified between ctHPV-DNA kinetics and patients' radiographic responses to chemotherapy.
KEY EVIDENCE: Significant correlation coefficients were observed, indicating reliable patterns in tumor DNA levels and treatment outcomes.
APPROACH: The analysis utilized data on ctHPV-DNA from patients receiving neoadjuvant chemotherapy for oropharyngeal cancer.
SIGNIFICANCE: Findings suggest that monitoring ctHPV-DNA could inform treatment strategies and improve patient outcomes in oropharyngeal cancer.

Implication

Analysis shows correlation between circulating tumor HPV-DNA levels and radiographic response in HPV-related oropharyngeal cancer, suggesting potential for treatment adaptation.

Abstract

Supplemental Table 2. Correlation coefficients (p-values) for ctHPV-DNA kinetics and radiographic response following neoadjuvant chemotherapy.

Discussion

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Cite This Study

Rosenberg et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcb4 https://doi.org/10.1158/1078-0432.29761072

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Supplemental Table 2 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplemental Table 2 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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