Supplemental Table 3 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Ari J. Rosenberg; Evgeny Izumchenko; Aditya Juloori; Rohan Katipally; John Cursio; Noura J. Choudhury; Zhen Gooi; Elizabeth A. Blair; Jeffrey Chin; Rifat Hasina; Augustin Vannier; Anna Starus; Frederick S. Jones; Emily L. Gramiccioni; Yuxuan Miao; Daniel J. Haraf; Everett E. Vokes; Alexander T. Pearson; Nishant Agrawal

doi:10.1158/1078-0432.29761069

Key Points

MAIN FINDING: Significant discordance observed between deep radiographic response and ctHPV-DNA clearance after the first cycle of chemotherapy.
KEY EVIDENCE: Over 50% tumor shrinkage was not consistently linked with a 95% reduction in ctHPV-DNA levels post-treatment.
APPROACH: The analysis utilized RECIST v1.1 criteria to evaluate tumor response and monitored circulating tumor HPV-DNA levels in patients.
SIGNIFICANCE: Findings challenge traditional metrics of treatment success, emphasizing the need for adaptive treatment strategies in oropharyngeal cancer.

Implication

Analysis reveals discordance in radiographic response and ctHPV-DNA clearance after neoadjuvant chemotherapy in oropharyngeal cancer patients, suggesting complexity in treatment response.

Abstract

Supplemental Table 3. Discordance between deep radiographic response (>50% tumor shrinkage per RECIST v1.1) and rapid ctHPV-DNA clearance (≥95% reduction) after 1 cycle.

Discussion

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Cite This Study

Rosenberg et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcb2 https://doi.org/10.1158/1078-0432.29761069

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Supplemental Table 3 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplemental Table 3 from Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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