Pregnancy with osteogenesis imperfecta: A scoping review

<ns7:p>Purpose Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by genotype and phenotypic heterogeneity. Limited literature is available regarding pregnancy with OI. Objectives The objective is to capture the available literature on OI and pregnancy. Methods A scoping review methodology was used to record and summarize the existing research evidence. The review process was conducted following the PRISMA-ScR guidelines. Three databases (Pubmed, Embase, web of science) were searched systematically. Literature published between 1975-2024 was extracted. Original studies mentioning OI with a minimum of 25 pregnancies were included. Results 546 articles were identified for title and abstracts screening. 28 records were reviewed for full text; seven studies met the inclusion criteria and were included. Reference details, study characteristics, topics of interest, and main findings are presented. The review showed that cesarian delivery was more common. Prolonged breast feeding was a risk factor for the occurrence of maternal fractures after pregnancies. OI pregnancies are at risk of increased neonatal morbidities, and congenital anomalies consistently. Conclusion There are significant data gaps in the literature concerning the experience of OI and pregnancy outcomes. This study underscores the crucial need for further research and clarity about maternal and neonatal complications associated with OI pregnancies.</ns7:p>