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August 1, 2025

Figure S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli Basu Erin L. Marcotte Tianzhong Yang

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Key Points

MAIN FINDING: The study identifies candidate genes linked to hepatoblastoma through transcriptome-wide association.
KEY EVIDENCE: Analysis of imputed gene expression demonstrated its significant impact on hepatoblastoma risk.
APPROACH: The research utilized multiancestry data and performed METRO and METRO-Egger analysis.
SIGNIFICANCE: Discovering these genes may enhance understanding and lead to improved risk assessment for hepatoblastoma.

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Implication

Transcriptome-wide association study reveals candidate genes affecting hepatoblastoma risk using gene expression analysis.

Abstract

Plots comparing the effect of imputed gene expression on hepatoblastoma risk by METRO and METRO-Egger Analysis (250kb)

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d00eb https://doi.org/10.1158/1055-9965.29762077

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
2Figure S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
3Figure S5 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
4Figure S11 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
5Table S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
6Table S4 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
7Table S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
8Table S5 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025