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August 1, 2025

Figure S7 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli Basu Erin L. Marcotte Tianzhong Yang

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Key Points

MAIN FINDING: The transcriptome-wide association study highlights key genes linked to hepatoblastoma risk.
KEY EVIDENCE: Analysis involved plotting imputed gene expression effects on risk, utilizing METRO and METRO-Egger.
APPROACH: The study conducted extensive data comparisons across multiple ancestries to identify gene associations.
SIGNIFICANCE: This research enhances understanding of genetic factors influencing hepatoblastoma, guiding future studies and treatments.

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Implication

Analysis reveals candidate genes associated with hepatoblastoma risk through multiancestry approaches, indicating vital genetic factors.

Abstract

Plots comparing the effect of imputed gene expression on hepatoblastoma risk by METRO and METRO-Egger Analysis (500kb)

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0131 https://doi.org/10.1158/1055-9965.29762056

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
2Figure S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
3Figure S5 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
4Figure S11 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
5Table S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
6Table S4 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
7Table S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
8Table S5 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025