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August 1, 2025

Figure S11 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli Basu Erin L. Marcotte Tianzhong Yang

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Key Points

Main finding highlights candidate genes associated with hepatoblastoma identified through a transcriptome-wide association study.
Significant medium transcripts per million were recorded for METRO findings, particularly at 200kb and 500kb regions.
The study used adult GTEx liver tissue samples, enabling a detailed analysis of gene expression patterns.
This research enhances the understanding of genetic factors in hepatoblastoma, potentially guiding future therapeutic strategies.

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Implication

Transcriptome-wide association study finds candidate genes linked to hepatoblastoma in GTEx liver tissue, suggesting new insights into this cancer.

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d00f2 https://doi.org/10.1158/1055-9965.29762080

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
2Figure S7 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
3Figure S5 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
4Figure S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
5Figure S4 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
6Table S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
7Table S6 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
8Table S5 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025