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August 1, 2025

Figure S10 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli Basu Erin L. Marcotte Tianzhong Yang

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Key Points

MAIN FINDING: The study identifies candidate genes that are significantly associated with hepatoblastoma.
KEY EVIDENCE: Differential gene expression analyses show distinct patterns between normal liver and HB tumors.
APPROACH: The research utilizes a transcriptome-wide association study approach to uncover genetic links.
SIGNIFICANCE: Findings could help in understanding hepatoblastoma and developing targeted therapies for the disease.

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Implication

This association study reveals differential gene expression in hepatoblastoma, suggesting potential candidate genes linked to the tumor.

Abstract

Normal liver vs. HB tumor differential gene expression analyses.

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d00f5 https://doi.org/10.1158/1055-9965.29762083

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S8 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
2Figure S9 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
3Figure S4 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
4Table S12 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
5Table S10 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
6Table S11 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
7Table S7 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
8Figure S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025