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August 1, 2025

Figure S9 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli Basu Erin L. Marcotte Tianzhong Yang

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Key Points

MAIN FINDING: The study identifies candidate genes linked to hepatoblastoma through transcriptome analysis.
KEY EVIDENCE: Differential expression analysis shows the top 6 down-regulated genes in the Japanese cohort.
APPROACH: The research utilizes normalized gene counts and Log2 fold change metrics to evaluate gene expression.
SIGNIFICANCE: This work enhances understanding of hepatoblastoma genetics, potentially guiding future research and treatments.

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Implication

Transcriptome-wide association study reveals top down-regulated genes in hepatoblastoma with significant implications for genomic research.

Abstract

Plotted differential expression of normalized gene counts for the top 6 down-regulated genes by Log2 fold changes (LFC) for the Japanese HB cohort.

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0106 https://doi.org/10.1158/1055-9965.29762050

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Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S8 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
2Figure S10 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
3Table S12 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
4Figure S4 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
5Table S10 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
6Figure S7 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
7Figure S2 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025
8Table S11 from Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma2025