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August 1, 2025

Figure S3 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression

Laura A. Smith Dalton M. Craven Alyssa N. Ho Elaine M. Glenny Erika T. Rezeli Meredith S. Carson Evan M. Paules Magdalena Fay Alyssa J. Cozzo Stephen D. Hursting Michael F. Coleman

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Key Points

Weight loss reverses the immunosuppressive effects of aging and obesity on mammary tumors.
GSEA analysis compares tumor characteristics between young DIO AL mice and other AL groups.
The findings indicate significant improvements in tumor progression with weight loss.
This research highlights potential therapeutic benefits of weight management in cancer treatment.

Implication

Analysis reveals that weight loss improves immunosuppression in mammary tumors of young DIO AL mice, suggesting potential cancer benefits.

Abstract

Figure S3 shows GSEA comparing tumors from Young DIO AL mice with those of all other AL groups.

Discussion

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Cite This Study

Smith et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d016d https://doi.org/10.1158/1940-6207.29760853

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S5 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
2Figure S4 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
3Figure S2 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
4Figure S1 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
5Data from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025 · 1 citations

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