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August 1, 2025

Figure S2 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression

Laura A. Smith Dalton M. Craven Alyssa N. Ho Elaine M. Glenny Erika T. Rezeli Meredith S. Carson Evan M. Paules Magdalena Fay Alyssa J. Cozzo Stephen D. Hursting Michael F. Coleman

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Key Points

Weight loss significantly reverses the effects of aging on mammary tumor progression.
Tumor growth was tracked over time with various interventions to measure effectiveness.
The study used animal models to simulate the impact of obesity on tumor development.
Findings suggest that addressing weight issues can improve cancer treatment outcomes and immune response.

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Implication

Interventions reduced tumor growth in models of obesity and aging, suggesting weight loss can ameliorate immunosuppression.

Abstract

Figure S2 shows tumor growth over time following various interventions.

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Cite This Study

Smith et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d016e https://doi.org/10.1158/1940-6207.29760859

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
2Figure S3 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
3Figure S4 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
4Figure S5 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
5Data from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025 · 1 citations

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