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August 1, 2025

Figure S4 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression

Laura A. Smith Dalton M. Craven Alyssa N. Ho Elaine M. Glenny Erika T. Rezeli Meredith S. Carson Evan M. Paules Magdalena Fay Alyssa J. Cozzo Stephen D. Hursting Michael F. Coleman

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Key Points

Weight loss reverses immunosuppression effects linked to aging and obesity in mammary tumors.
GSEA analysis shows differences between tumors from young and older ICR mice.
Research utilized ICR mice to investigate tumor responses to aging and weight changes.
Findings indicate that addressing obesity may improve tumor outcomes and immunological health.

Implication

Weight loss improves immunosuppression in mammary tumors from aging and obese mice, suggesting therapeutic potential.

Abstract

Figure S4 shows GSEA comparing tumors from Young Con ICR mice with those of all other ICR groups.

Discussion

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Cite This Study

Smith et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01a6 https://doi.org/10.1158/1940-6207.29760850

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S5 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
2Figure S3 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
3Figure S2 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
4Figure S1 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
5Data from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025 · 1 citations

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