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August 1, 2025

Figure S5 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression

Laura A. Smith Dalton M. Craven Alyssa N. Ho Elaine M. Glenny Erika T. Rezeli Meredith S. Carson Evan M. Paules Magdalena Fay Alyssa J. Cozzo Stephen D. Hursting Michael F. Coleman

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Key Points

MAIN FINDING: Weight loss significantly reverses immunosuppression effects caused by aging and obesity on mammary tumors.
KEY EVIDENCE: GSEA analysis shows distinct tumor characteristics in young mice on different diets compared to obese counterparts.
APPROACH: The study used genetic enrichment analysis to compare tumors from various young mouse models.
SIGNIFICANCE: These findings suggest that managing weight can potentially enhance immune responses in cancer treatment.

Implication

GSEA reveals differences in tumor profiles between young and obese mice, indicating weight loss may improve immune response.

Abstract

Figure S5 shows GSEA comparing tumors from Young Con AL mice with those of Young DIO ICR, Young DIO CCR, and Young DIO AL-LFD (GSE272329).

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Cite This Study

Smith et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0171 https://doi.org/10.1158/1940-6207.29760841

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
2Figure S4 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
3Figure S2 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
4Figure S1 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025
5Data from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression2025 · 1 citations

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