August 2, 2025

Supplementary Fig.S15 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

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MAIN FINDING: Somatic mutation timing provides insight into the evolutionary trajectory of lung adenocarcinoma.
KEY EVIDENCE: Mutation frequencies differed significantly between smokers and non-smokers in Asian cohorts.
APPROACH: Analysis compared mutation data from NHLCC and East Asian cohorts to TCGA data.
SIGNIFICANCE: Findings enhance understanding of lung adenocarcinoma evolution and guide future research on targeted therapies.

Implication

Comparison reveals mutation frequencies of driver genes in Asian cohorts and TCGA, indicating smoking status impacts results.

Comparison of the mutation frequencies of driver genes between Asian cohorts (NHLCC and East Asian) and TCGA cohorts among smokers and non-smokers.

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Qin et al. (2025) studied this question.

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Comparison reveals mutation frequencies of driver genes in Asian cohorts and TCGA, indicating smoking status impacts results.

Comparison of the mutation frequencies of driver genes between Asian cohorts (NHLCC and East Asian) and TCGA cohorts among smokers and non-smokers.