August 2, 2025

Supplementary Fig.S13 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

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MAIN FINDING: The study identifies differences in early clonal mutations related to smoking status and gender in lung adenocarcinoma.
KEY EVIDENCE: Data show a higher frequency of somatic mutations in driver genes among smokers compared to non-smokers.
APPROACH: The analysis compared mutations across different patient demographics, focusing on clonal mutation timing.
SIGNIFICANCE: This research enhances understanding of lung adenocarcinoma's evolution, potentially guiding personalized treatment strategies.

Implication

Comparison reveals early clonal mutations in driver genes based on smoking status and gender, suggesting distinct evolutionary trajectories.

Comparison of the frequency of early clonal mutations in driver genes among patients with different smoking status or gender.

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Qin et al. (2025) studied this question.

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Comparison reveals early clonal mutations in driver genes based on smoking status and gender, suggesting distinct evolutionary trajectories.

Comparison of the frequency of early clonal mutations in driver genes among patients with different smoking status or gender.