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August 1, 2025

Supplementary Figure 2 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

Shuling Han Luying Cui Bojun Wang Yuli Ruan Mengde Shi Chang Hong Xin Guan Zhuo Chen Yingjue Li Yuanyu Liao Ming Ma Xiaolin Lu Andi Wang Yanqiao Zhang Chao Liu

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Key Points

USP15 promotes tumor growth in colorectal cancer models with functional immune systems.
Myeloid-derived suppressor cells are recruited through the SMYD3/CCL2 pathway by USP15.
The study used immunocompetent mice to assess the effects on tumor dynamics.
Understanding this mechanism could have significant implications for colorectal cancer treatments.

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Implication

Research reveals USP15 enhances immune evasion in colorectal cancer, suggesting myeloid-derived suppressor cells play a key role.

Abstract

USP15 promotes tumor growth in CRC immunocompetent mice models.

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Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01e7 https://doi.org/10.1158/2326-6066.29760274

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
2Supplementary Figure 10 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
3Supplementary Figure 3 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
4Supplementary Figure 9 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
5Supplementary Figure 7 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025