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August 1, 2025

Supplementary Figure 1 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

Shuling Han Luying Cui Bojun Wang Yuli Ruan Mengde Shi Chang Hong Xin Guan Zhuo Chen Yingjue Li Yuanyu Liao Ming Ma Xiaolin Lu Andi Wang Yanqiao Zhang Chao Liu

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Key Points

USP15 shows increased levels in colorectal cancer, correlating with a worse prognosis.
The study identifies Myeloid-Derived Suppressor Cells as key players in immune evasion linked to USP15.
SMYD3 and CCL2 pathways are involved in the recruitment of immune cells in cancer environments.
Targeting USP15 may offer new therapeutic strategies to enhance immune responses against colorectal cancer.

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Implication

Research demonstrates USP15 promotes immune evasion in colorectal cancer, suggesting implications for treatment targeting SMYD3 and CCL2.

Abstract

USP15 is upregulated and correlates with poor prognosis in CRC.

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Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01ed https://doi.org/10.1158/2326-6066.29760289

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
2Supplementary Figure 3 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
3Supplementary Figure 7 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
4Supplementary Figure 10 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
5Supplementary Figure 8 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025