⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

August 1, 2025

Supplementary Figure 9 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

Shuling Han Luying Cui Bojun Wang Yuli Ruan Mengde Shi Chang Hong Xin Guan Zhuo Chen Yingjue Li Yuanyu Liao Ming Ma Xiaolin Lu Hong Wang Yanqiao Zhang Chao Liu

View Full Paper

Ask AI

Bookmark

Share

Key Points

Blocking usp15 enhances anti-pd-1 therapy effects in colorectal cancer models.
The study shows that usp15 is involved in immune evasion through myeloid-derived suppressor cell recruitment.
MDSCs are reprogrammed in the presence of anti-pd-1 therapy when usp15 is inhibited.
Findings indicate that targeting usp15 may improve cancer treatment strategies by boosting anti-tumor immunity.

Implication

Blocking usp15 improves anti-pd-1 therapy effectiveness in colorectal cancer models, suggesting immune response enhancement.

Abstract

Blocking USP15 augments the anti-PD-1 therapy in CRC Models through MDSCs reprogramming.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d025e https://doi.org/10.1158/2326-6066.29760244

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 3 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
2Supplementary Figure 2 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
3Supplementary Figure 10 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
4Supplementary Figure 1 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
5Supplementary Figure 7 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025