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August 1, 2025

Supplementary Figure 3 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

Shuling Han Luying Cui Bojun Wang Yuli Ruan Mengde Shi Chang Hong Xin Guan Zhuo Chen Yingjue Li Yuanyu Liao Ming Ma Xiaolin Lu Andi Wang Yanqiao Zhang Chao Liu

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Key Points

USP15 significantly increases myeloid-derived suppressor cell (MDSC) infiltration in the colorectal cancer (CRC) environment.
The study reveals a correlation between high MDSC numbers and reduced CD8+ T cell presence in CRC tissues.
Analysis utilized a combination of flow cytometry and immunohistochemistry to assess immune cell populations in the CRC microenvironment.
Understanding USP15's role in immune evasion could inform new therapeutic strategies against CRC.

Implication

Research demonstrates that USP15 triggers high MDSC recruitment and decreases CD8+ T cells in CRC, suggesting immune evasion mechanisms.

Abstract

USP15 induces high MDSC infiltration and low CD8+T cells infiltration in the CRC microenvironment.

Discussion

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Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01e9 https://doi.org/10.1158/2326-6066.29760271

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 9 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
2Supplementary Figure 2 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
3Supplementary Figure 1 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
4Supplementary Figure 8 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025
5Supplementary Figure 7 from USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment2025