Figure S2 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee; Kyunghwan Kim; Hye‐Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon‐gyeong Lee; Eun A Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung‐Jae Myung; Deok‐Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae‐Eun Park; Jinmyoung Joo; Seung Woo Cho

doi:10.1158/0008-5472.29760188

Key Points

Multiplexed crispr/cas9 systems were tested to assess their effects on cancer cell viability.
Different delivery methods, including rnp- and rna-based systems, were utilized for treatment.
Representative images illustrate the varying impacts of crispr/cas9 on multiple cancer cell types.
The findings highlight the potential for combining parp inhibitors with crispr for targeted cancer therapies.

Implication

Figure S2 shows the impact of multiplexed crispr delivery on cell viability in various cancer cell lines, suggesting potential treatment pathways.

Abstract

Figure S2 presents representative images demonstrating the effect of RNP- or RNA-based delivery of multiplexed CRISPR/Cas systems on cell viability in various cancer cell lines.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0222 https://doi.org/10.1158/0008-5472.29760188

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Figure S2 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S2 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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