Figure S7 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

MAIN FINDING: Multiplexed sgRNAs targeting proximal sites near C4BPB gene show no cytotoxic effects on cancer cells.
KEY EVIDENCE: Bright-field images confirm that the applied sgRNAs remain non-toxic, ensuring safer gene editing.
APPROACH: The research employs a combination of CRISPR/Cas9-nickase and PARP inhibitors to target cancer effectively.
SIGNIFICANCE: This method improves precision in targeting cancer cells, potentially leading to safer therapeutic options.

Bright-field images reveal multiplexed sgRNAs near C4BPB gene do not induce cytotoxic effects in cancer cells, suggesting safe targeting strategies.

Figure S7 presents bright-field images showing that multiplexed sgRNAs targeting proximal sites near the C4BPB gene do not induce cytotoxic effects.

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Lee et al. (2025) studied this question.

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