Figure S5 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee; Kyunghwan Kim; Hye‐Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon‐gyeong Lee; Eun A Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung‐Jae Myung; Deok‐Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae‐Eun Park; Jinmyoung Joo; Seung Woo Cho

doi:10.1158/0008-5472.29760173

Key Points

MAIN FINDING: CRISPR-induced cytotoxicity can effectively target cancer cells through four intergenic sgRNAs.
KEY EVIDENCE: The sgRNAs showed a significant ability to induce cell death, independent of gene function.
APPROACH: The study analyzed the genomic context of the sgRNAs used alongside PARP inhibitors.
SIGNIFICANCE: This combination therapy may lead to innovative approaches for cancer treatment, improving precision in targeting.

Implication

Experimental findings demonstrate cell death induced by genomic context of sgRNAs in cancer cells, implying new treatment strategies.

Abstract

Figure S5 shows the genomic context of four intergenic sgRNAs that effectively induced cell death, demonstrating that CRISPR-induced cytotoxicity can occur independently of gene function.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d026f https://doi.org/10.1158/0008-5472.29760173

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Figure S5 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S5 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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