Figure S10 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee; Kyunghwan Kim; Hye‐Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon‐gyeong Lee; Eun A Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung‐Jae Myung; Deok‐Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae‐Eun Park; Jinmyoung Joo; Seung Woo Cho

doi:10.1158/0008-5472.29760215

Key Points

The study demonstrates the antitumor effects of sgRNA-loaded liposomes using HCT-116 cells.
Results indicate that combining CRISPR and PARP inhibitors enhances targeting of cancer cells effectively.
In vivo experiments were conducted in a mouse xenograft model to evaluate therapeutic effects.
This approach may advance cancer treatment strategies by improving precision in targeting cancer cells.

Implication

In vivo tests assess antitumor effects of sgRNA-loaded liposomes on HCT-116 cancer cells, suggesting effective targeting in cancer therapy.

Abstract

Figure S10 evaluates the in vivo antitumor effects of sgRNA-loaded liposomes in a mouse xenograft model using HCT-116 cells stably expressing Cas9 nucleases.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0276 https://doi.org/10.1158/0008-5472.29760215

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Figure S10 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S10 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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