Figure S8 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee; Kyunghwan Kim; Hye‐Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon‐gyeong Lee; Eun A Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung‐Jae Myung; Deok‐Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae‐Eun Park; Jinmyoung Joo; Seung Woo Cho

doi:10.1158/0008-5472.29760161

Key Points

MAIN FINDING: CRISPR/Cas9 coupled with lipid nanoparticles shows promise in targeting cancer cells effectively.
KEY EVIDENCE: The combination demonstrates enhanced therapeutic potential in HCT-116 xenograft tumor models.
APPROACH: Evaluated the delivery mechanism of multiplexed CRISPR/Cas9 RNPs using lipid nanoparticles.
SIGNIFICANCE: This method could lead to more precise cancer therapies, improving treatment outcomes.

Implication

Therapeutic potential of lipid nanoparticles delivering multiplexed CRISPR/Cas9 in xenograft tumor models, indicating effective cancer targeting.

Abstract

Figure S8 evaluates the therapeutic potential of lipid nanoparticles (LNPs) delivering multiplexed CRISPR/Cas9 RNPs in HCT-116 xenograft tumor models.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d026a https://doi.org/10.1158/0008-5472.29760161

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Figure S8 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S8 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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