⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

August 1, 2025

Figure S15 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee Kyunghwan Kim Hye‐Jin Jeong Subin Choi Himchan Cheng Dayoung Kim Soomin Heo Jinhee Mun Minjong Kim Eunjin Lee Yoon Ji Choi Seon‐gyeong Lee Eun A Lee Yewon Jang Kayeong Lim Heon Seok Kim Euihwan Jeong Seung‐Jae Myung Deok‐Beom Jung Chang Sik Yu In Ho Song M. Ryan Corces Joo H. Kang Kyungjae Myung Taejoon Kwon Tae‐Eun Park Jinmyoung Joo Seung Woo Cho

View Full Paper

Ask AI

Bookmark

Share

Key Points

MAIN FINDING: LNP-mediated delivery of CRISPR/cas9 and olaparib effectively suppresses tumor growth.
KEY EVIDENCE: Experiments show significant tumor reduction when using the combined treatments in both in vitro and in vivo models.
APPROACH: The study utilized LNP (lipid nanoparticle) delivery to administer CRISPR/nCas9 and PARP inhibitors in cancer cells.
SIGNIFICANCE: This approach highlights the potential for precise cancer therapies using combined gene editing and pharmacological strategies.

Implication

Combining CRISPR/cas9-nickase and PARP inhibitors suppresses tumors in vitro and in vivo, indicating effective gene editing.

Abstract

Figure S15 shows tumor growth suppression through LNP-mediated delivery of CRISPR/nCas9 combined with olaparib, both in vitro and in vivo.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0223 https://doi.org/10.1158/0008-5472.29760191

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S12 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
2Figure S13 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
3Figure S11 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
4Figure S8 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
5Figure S6 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025