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August 1, 2025

Figure S13 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee Kyunghwan Kim Hye‐Jin Jeong Subin Choi Himchan Cheng Dayoung Kim Soomin Heo Jinhee Mun Minjong Kim Eunjin Lee Yoon Ji Choi Seon‐gyeong Lee Eun A Lee Yewon Jang Kayeong Lim Heon Seok Kim Euihwan Jeong Seung‐Jae Myung Deok‐Beom Jung Chang Sik Yu In Ho Song M. Ryan Corces Joo H. Kang Kyungjae Myung Taejoon Kwon Tae‐Eun Park Jinmyoung Joo Seung Woo Cho

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Key Points

Main finding shows that combining crispr and parp inhibitors effectively targets cancer cells.
Key evidence indicates olaparib inhibits dna repair of single-strand breaks caused by crispr/nCas9D10A.
Approach utilized multiplexed crispr/nCas9D10A and parp inhibitors to assess their combined effects.
Significance lies in potential therapeutic strategies for enhancing cancer cell targeting and treatment efficacy.

Implication

Figure S13 demonstrates the impact of olaparib on DNA repair in cancer cells, suggesting a therapeutic approach.

Abstract

Figure S13 demonstrates the inhibitory role of olaparib in the repair of DNA single-strand breaks induced by multiplexed CRISPR/nCas9D10A.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0224 https://doi.org/10.1158/0008-5472.29760200

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S12 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
2Figure S15 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
3Figure S6 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
4Figure S4 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
5Table S1 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025