Table S3 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee; Kyunghwan Kim; Hye‐Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon‐gyeong Lee; Eun A Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung‐Jae Myung; Deok‐Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae‐Eun Park; Jinmyoung Joo; Seung Woo Cho

doi:10.1158/0008-5472.29760143

Key Points

Combining CRISPR/nickase with PARP inhibitors enhances precision in targeting cancer cells.
Table S3 details sequences and genomic coordinates for effective CRISPR/sgRNA applications.
The study identifies potential off-targets, ensuring higher specificity in gene editing.
This approach shows promise in improving cancer therapies by minimizing unintended genetic effects.

Implication

Combination of CRISPR/Cas9-nickase and PARP inhibitors effectively targets cancer cells, highlighting off-target analysis.

Abstract

Table S3 describes the information of the target sequences of CRISPR/sgRNA, which includes the sequences, genomic coordinates, and number of putative off-targets.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0265 https://doi.org/10.1158/0008-5472.29760143

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Table S3 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Table S3 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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