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August 1, 2025

Table S4 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Soyoung Lee Kyunghwan Kim Hye‐Jin Jeong Subin Choi Himchan Cheng Dayoung Kim Soomin Heo Jinhee Mun Minjong Kim Eunjin Lee Yoon Ji Choi Seon‐gyeong Lee Eun A Lee Yewon Jang Kayeong Lim Heon Seok Kim Euihwan Jeong Seung‐Jae Myung Deok‐Beom Jung Chang Sik Yu In Ho Song M. Ryan Corces Joo H. Kang Kyungjae Myung Taejoon Kwon Tae‐Eun Park Jinmyoung Joo Seung Woo Cho

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Key Points

MAIN FINDING: Combining CRISPR/Cas9-nickase with PARP inhibitors effectively targets cancer cells.
KEY EVIDENCE: Putative off-target sites of sgRNA were identified using Cas-Offinder and CRISPOR analysis.
APPROACH: The analysis focused on sgRNA in Hmix-4 to ensure precise targeting of cancer cells.
SIGNIFICANCE: This method improves the accuracy of gene editing in cancer treatment, reducing side effects.

Implication

Analysis identifies off-target sgRNA sites in hmix-4, suggesting precision in targeting cancer cells.

Abstract

Table S4 provides information on the putative off-target sites of each sgRNA in Hmix-4, as identified by Cas-Offinder and CRISPOR analyses.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0242 https://doi.org/10.1158/0008-5472.29760137

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Keep reading

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1Table S3 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
2Figure S4 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
3Table S1 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
4Figure S7 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025
5Figure S5 from Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells2025