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August 4, 2025Bioscientia Medicina Journal of Biomedicine and Translational ResearchOpen Access

Beyond the Species Barrier: A Systematic Review and Risk of Bias Assessment on the Efficacy, Safety, and Translational Potential of Xenogenic Platelet-Rich Plasma for Wound Healing

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Authors

KYKharisma Naufal YudantonoUSUdadi SadhanaYBYuriz Bakhtiar

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Overview

Systematic review assesses efficacy and safety of xenogenic platelet-rich plasma in wound healing, highlighting potential despite bias risks.

Key Points

  • Xenogenic platelet-rich plasma shows significant improvements in wound healing outcomes like closure rates and collagen deposition.
  • Evidence from multiple animal studies indicates a 45% acceleration in wound closure with porcine-derived xPRP compared to controls.
  • The review reveals high risk of bias among studies due to issues with study design and methodology.
  • Despite promising results, further rigorous clinical trials are needed to confirm xPRP's translational potential in humans.

Cite This Study

Yudantono et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0851https://doi.org/10.37275/bsm.v9i10.1400
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence Based Efficacy of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Acute and Chronic Wound Healing: A Retrospective Case Series2025
  2. 2Platelet-Rich Plasma for Burn Wound Healing in Preclinical Models: A Systematic Review of Efficacy and Biomolecular Mechanisms2025
  3. 3A Single-Institution Cohort Study of Autologous Platelet-Rich Plasma Gel for Hard-to-Heal Chronic Wounds: Potential Role in Microvascular Regeneration2026
  4. 4PLATELET-RICH PLASMA (PRP) IN MODERN DERMATOLOGY AND AESTHETIC MEDICINE: BIOLOGICAL MECHANISMS, CLINICAL APPLICATIONS, AND FUTURE DIRECTIONS2026
  5. 5Platelet-Rich Plasma (PRP) and Recombinant Growth Factor Therapies in Cutaneous Wound Healing: Mechanisms, Clinical Applications, and Future Directions2025