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August 4, 2025

Figure S7 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer

Catherine S. Johnson Diane L. Costanzo-Garvey Julio C. Valencia Sanjana Rajgopal Theodore Reed Emma R. Brannon Jeremy S. Frieling Deanna D. Mosley Todd A. Wyatt Elijah F. Edmondson Kabhilan Mohan Grinu Mathew Leah M. Cook

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Key Points

Cxcl1 knockout MSCs effectively suppress growth in the C42B prostate cancer model.
The regulated immune environment is a key factor in the suppression observed.
The study utilized mesenchymal stem cells to explore impacts on osteogenesis and cancer growth.
Understanding cxcl1's role opens avenues for improved cancer therapies and treatments.

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Implication

Targeted deletion of cxcl1 in mesenchymal stem cells suppresses growth of bone-metastatic prostate cancer, suggesting immune regulation.

Abstract

Cxcl1 KO MSCs suppresses C42B growth and regulates the immune environment

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Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0959 https://doi.org/10.1158/1541-7786.29819718

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S5 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
2Figure S2 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
3Figure S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
4Figure S3 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
5Table S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025