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August 4, 2025

Table S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer

Catherine S. Johnson Diane L. Costanzo-Garvey Julio C. Valencia Sanjana Rajgopal Theodore Reed Emma R. Brannon Jeremy S. Frieling Deanna D. Mosley Todd A. Wyatt Elijah F. Edmondson Kabhilan Mohan Grinu Mathew Leah M. Cook

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Key Points

CXCL1 deletion from MSCs shows potential to regulate osteogenesis and inhibit tumor growth.
The study utilizes sgRNA sequences to generate knockout MSCs for investigating osteogenesis.
Findings indicate that changes in CXCL1 expression can impact prostate cancer metastasis in bone.
This research highlights the role of genetic deletion in understanding cancer progression and bone health.

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Implication

Targeted deletion of cxcl1 regulates osteogenesis in MSCs, suggesting it may inhibit bone-metastatic prostate cancer.

Abstract

sgRNA sequences for Generation of Cxcl1 KO MSCs

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Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0928 https://doi.org/10.1158/1541-7786.29819715

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S3 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
2Figure S7 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
3Figure S5 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
4Figure S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
5Figure S2 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025