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August 4, 2025

Figure S2 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer

Catherine S. Johnson Diane L. Costanzo-Garvey Julio C. Valencia Sanjana Rajgopal Theodore Reed Emma R. Brannon Jeremy S. Frieling Deanna D. Mosley Todd A. Wyatt Elijah F. Edmondson Kabhilan Mohan Grinu Mathew Leah M. Cook

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Key Points

Targeted deletion of cxcl1 in msCs influences osteogenesis, impacting bone health.
Cxcl1 knockout results in significant alterations in collagen and ecm pathways within msCs.
The study utilized mouse models to analyze changes in bone-morphic characteristics related to prostate cancer.
Findings may point to new therapeutic strategies for managing bone-metastatic prostate cancer.

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Implication

Targeted deletion of cxcl1 in msCs alters collagen and ecm pathways, suggesting implications for prostate cancer treatment.

Abstract

Cxcl1 KO MSCs Have Altered Collagen and ECM Pathway

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Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d10fa https://doi.org/10.1158/1541-7786.29819733

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
2Figure S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
3Figure S5 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
4Figure S3 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
5Table S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025