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August 4, 2025

Table S3 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer

Catherine S. Johnson Diane L. Costanzo-Garvey Julio C. Valencia Sanjana Rajgopal Theodore Reed Emma R. Brannon Jeremy S. Frieling Deanna D. Mosley Todd A. Wyatt Elijah F. Edmondson Kabhilan Mohan Grinu Mathew Leah M. Cook

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Key Points

MAIN FINDING: Targeted deletion of cxcl1 in mesenchymal stem cells (MSCs) regulates osteogenesis and impacts prostate cancer.
KEY EVIDENCE: GSEA of cxcl1 knockdown shRNA MSCs shows significant changes in gene expression related to bone health.
APPROACH: RNA sequencing was used to analyze the effects of cxcl1 deletion on MSCs in the context of cancer.
SIGNIFICANCE: Findings suggest therapeutic potential of manipulating cxcl1 in MSCs for treating bone-related diseases.

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Implication

GSEA analysis reveals altered osteogenesis and suppressed bone-metastatic prostate cancer in MSCs with Cxcl1 deletion.

Abstract

GSEA of Cxcl1 KD shRNA MSCs RNA Sequencing Results

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Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0956 https://doi.org/10.1158/1541-7786.29819709

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
2Figure S1 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
3Figure S7 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
4Figure S2 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025
5Figure S5 from Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer2025