Supplementary Figure S17 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: Single-cell eQTL mapping reveals distinct genetic control mechanisms across cell subtypes in colorectal cancer.
KEY EVIDENCE: Cell-to-cell interaction analyses indicate how different subtypes evolve during malignant transformation.
APPROACH: The study utilized single-cell analysis to map genetic influences at various stages of colorectal cancer development.
SIGNIFICANCE: Understanding subtype-specific genetic control enhances knowledge of colorectal cancer progression and potential treatments.

Cell interaction analyses reveal genetic control mechanisms in colorectal cancer, suggesting subtype-specific influences.

Supplementary Figure 17 shows cell-to-cell interaction analyses in different stages of colorectal cancer development.

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Chen et al. (2025) studied this question.

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