Supplementary Figure S14 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Single-cell eQTL mapping reveals specific genetic controls influencing T cell behavior in colorectal cancer.
T cell expression profiles change at different stages of colorectal cancer development, indicating cellular dynamics.
The analysis focuses on the malignant transformation process, highlighting how genetics affect cell types.
Understanding these mechanisms can help develop targeted therapies for colorectal cancer based on individual cell subtypes.

Single-cell eQTL mapping reveals genetic control mechanisms in T cells throughout colorectal cancer progression, indicating subtype specificity.

Supplementary Figure 14 shows the expression profiles of T cells in different stages of colorectal cancer development.

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Chen et al. (2025) studied this question.

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