Supplementary Figure S11 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: The research uncovers genetic control of endothelial cells during colorectal cancer progression.
KEY EVIDENCE: Expression profiles were analyzed at different stages, revealing specific genetic influences.
APPROACH: Single-cell eQTL mapping was utilized to link genetic variations to cellular behaviors in cancer.
SIGNIFICANCE: Understanding these mechanisms may lead to targeted therapies for colorectal cancer.

Single-cell eQTL mapping demonstrates cell subtype-specific genetic control and implications for malignant transformation in colorectal cancer.

Supplementary Figure 11 shows the expression profiles of endothelial cells in different stages of colorectal cancer development.

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Chen et al. (2025) studied this question.

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