Supplementary Figure S9 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: The study highlights that genetic control varies among fibroblast subtypes during colorectal cancer progression.
KEY EVIDENCE: Expression profiles of fibroblasts at different cancer stages illustrate distinct genetic influences on their behavior.
APPROACH: Single-cell eQTL mapping was used to identify genetic factors affecting fibroblast roles in cancer.
SIGNIFICANCE: Understanding fibroblast genetic control can enhance insights into colorectal cancer development and potential therapies.

Single-cell eQTL analysis reveals genetic control of malignant transformation in colorectal cancer, indicating specific mechanisms in fibroblasts.

Supplementary Figure 9 shows the expression profiles of fibroblasts in different stages of colorectal cancer development.

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Chen et al. (2025) studied this question.

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