Supplementary Figure S8 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: Cell subtype-specific genetic factors influence the malignant transformation in colorectal cancer.
KEY EVIDENCE: Analysis of fibroblast subsets highlights differential proportions linked to genetic control mechanisms.
APPROACH: Single-cell eQTL mapping was utilized to assess genetic variations among distinct cell types.
SIGNIFICANCE: Understanding these mechanisms could improve targeted therapies for colorectal cancer patient subtypes.

Supplementary figure shows fibroblast subset differences in genetic control, indicating subtype-specific mechanisms in colorectal cancer.

Supplementary Figure 8 shows cell markers and differential proportions of fibroblast subsets.

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Chen et al. (2025) studied this question.

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