Supplementary Figure S3 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Can Chen; Yimin Cai; Wenlong Hu; Kai Tan; Zequn Lu; Xuanyu Zhu; Ziying Liu; Chunyi He; Guangping Xu; Ruizhe Zhang; Caibo Ning; Shuheng Ruan; Jiayan Gao; Xiaojun Yang; Yongchang Wei; Xu Zhu; Xiangpan Li; Faxi Wang; Fubing Wang; Jiaoyuan Li; Meng Jin; Bin Li; Ying Zhu; Jianbo Tian; Xiaoping Miao

doi:10.1158/2159-8290.29819622

Key Points

Single-cell eQTL mapping identifies genetic control associated with cell subtype in colorectal cancer.
Differential proportions of epithelial subsets were observed, indicating variations in cancer development.
The research focused on elucidating mechanisms involved in malignant transformation specific to cell subtypes.
Findings can lead to improved understanding of colorectal cancer and potential therapeutic approaches targeting specific subtypes.

Implication

Single-cell eQTL mapping reveals genetic control and differential proportions of cell subtype in colorectal cancer, suggesting specific mechanisms in malignant transformation.

Abstract

Supplementary Figure 3 shows cell markers and differential proportions of epithelial subsets.

Discussion

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d095b https://doi.org/10.1158/2159-8290.29819622

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Supplementary Figure S3 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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